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The Psychology Behind Replies: Why People Respond to Some Emails and Ignore Others

Cameron Heffernan
December 18, 2025

Most cold emails fail not because of timing or formatting but because they forget there’s a person on the other side of the screen. Behind every “yes,” “no,” or silence lies a mix of curiosity, trust and perceived value.

For overseas-headquartered or overseas-based midmarket B2B companies and their U.S. subsidiaries, this distinction matters even more. The buyers and partners you’re trying to reach in the U.S. market are flooded with outreach. When your message speaks to how they think, feel, and decide, it stops feeling like noise and starts feeling like relevance.

Effective cold emails combine two parts: the art of communication and the science of

deliverability.

The Art

What You Say

The art is the human side of outreach, the part that connects on emotion and intent. It’s what makes your message feel like it came from a person, not a campaign. Speak to your reader’s goals, frustrations, or recent wins before you speak about your offer. People are driven more by their own priorities than by your product.

If your company is entering or scaling in the U.S., this mindset shift is critical. American buyers and partners expect clarity, confidence and relevance.

Subject Line

A subject line exists to earn the open, not make the sale. There’s no single formula, but personalization consistently performs best.

Instead of worrying whether it’s short or long, vague or detailed, focus on relevance. When the reader feels the subject line was written specifically for them, curiosity follows naturally.

Example:
“Noticed your new distribution site in Texas, congrats on the expansion.”

That feels conversational and aware of context, much more human than “Introducing our latest solution.”

First Outreach

The first email should start a conversation, not close a deal. A simple, personal observation followed by a curious question works better than a pitch.

Show awareness of something recent or specific: a new U.S. facility, a partnership announcement or a trade show appearance. Then, ask something that opens a genuine dialogue.

Example:
“Your Midwest expansion caught my eye. Curious how logistics are shaping up.”

This approach respects the reader’s time and builds credibility without selling.

Follow-Up Outreach

A follow-up shows reliability and persistence, not impatience. Keep it short, polite, and relevant. If your first email was personalized, don’t start over. Simply remind them of the context and lightly restate the value.

You can also use a follow-up to add value. Reference to a recent trend, regulation or industry development that affects their operations. For example:

“Hi again, I know your U.S. expansion plans are keeping you busy. I recently saw updated data from the U.S. Department of Commerce showing that industrial machinery imports rose 14% year over year, driven by reshoring and nearshoring investment. Are you seeing that trend in your area?”

Wait a few days before following up and keep your tone confident, not apologetic. The goal is to stay visible while offering something worthwhile. A good follow-up earns attention by being timely, respectful and useful.

Formatting

People skim before they read. The way your message looks determines whether it gets noticed.

- Keep sentences and paragraphs short
- Use spacing to separate key ideas
- Write in a way that feels light and easy to process

Your first email can be slightly longer since you’re introducing yourself and your intent. Follow-ups should be much shorter, two to three short paragraphs at most.

Example format:
Hi [Name],

I noticed your team is hiring in both Ohio and Texas. Looks like growth is picking up.

We’ve helped a few overseas companies improve brand visibility during that first U.S. scaling phase. Would you be open to a short exchange about what’s working?

This layout is easy on the eyes and feels natural to read.

Frequency

Timing affects how your message is perceived. The right rhythm depends on who you’re contacting and how busy they are.

- Corporate Executive (Fortune 500): Wait 3–4 weeks. Their inboxes are heavily filtered and often managed by assistants.
- Midmarket Executive ($50M–$150M): Wait 4–6 days. Reachable but balancing multiple priorities.
- Subsidiary or Regional Director: Wait 2–4 days. Often more accessible and directly accountable for growth.

Following up too often risks being flagged as spam, while following up too little makes you forgettable.

Who You Say It To

Targeting

Strong Outreach starts with clarity on who you want to reach. For overseas-based companies entering or growing in the U.S., this means mapping who actually influences purchasing or partnership decisions distributors, OEMs or regional buyers.

A targeted list increases open rates and protects your sender's reputation. Poor targeting does the opposite. It lowers engagement and signals to filter that your emails are irrelevant.

Seniority

It might seem easier to contact mid-level managers, but they rarely make final calls to partnerships or suppliers. While they may reply faster, those replies seldom lead to meaningful outcomes.

Reach out to people who can influence or approve of a decision. Thoughtful outreach to senior roles takes more time, but the quality of replies is far higher.

Role

Within every organization, influence flows differently. Identify who fits each of these roles:

- Global Decision-maker: Approves or purchases and drives global strategy (CEO, Founder, VP Global Sales)
- Head of the U.S. Subsidiary: VP Americas or General Manager, U.S.
- Champion: Builds internal support for working with your company (CRO, VP Key Accounts, Head of U.S. Sales)

When you understand each role’s motivation, your emails resonate more naturally.

Industry

Industry fluency builds credibility. Using the right context, terminology or trend shows that you understand what matters to your reader.

If you’re contacting a U.S. automotive or electronics manufacturer, reference supply chain shifts, tariffs or labor availability trends. Relevance makes your outreach worth reading.

Interest

Behavioral signals like website visits, downloads or event attendance reveal who’s paying attention. For example, if someone downloads a U.S. market-entry guide or attends your webinar, follow up while the topic is fresh.

Example:

“I saw your team downloaded our U.S. market-entry checklist. Curious which part felt most relevant: hiring, sales or distribution setup?”

These small touches make your outreach timely and personal.

Signals

Business activity also reveals intent. Job changes, expansion announcements or new U.S. facility openings indicate shifting priorities. Referencing those signals shows attention and timing.

If a company recently established a subsidiary or increased hiring in North America, acknowledge it and connect it to how you can help. Relevance based on real change is more powerful than a generic pitch.

The Science

Domain Setup

The science behind outreach ensures your message actually reaches its reader. Proper setup protects your reputation and prevents your emails from being flagged as spam.

Purchase one or more secondary domains from a trusted provider like GoDaddy or Namecheap. For example, if your website is company.com, your outreach domain could be company-mail.com. This keeps your main domain safe if deliverability issues arise.

Match configurations across your email host (Google Workspace, Outlook or Zoho) for consistency.

Authenticate your domain:
- SPF authorizes which servers can send on your behalf
- DKIM verifies your message wasn’t modified in transit
- DMARC tells receiving servers how to handle suspicious mail

Without these, even great emails can land in spam.

Preventing Issues

Deliverability depends on consistency and care:
- Enable domain privacy and protection
- Warm up new inboxes gradually
- Set realistic daily send limits
- Avoid spammy language (“Buy now,” “Free,” etc.)
- Include an unsubscribe option to stay compliant
- Track deliverability, spam rates and open rates regularly

Automation and Sequencing

Automation saves time but should never replace human touch. Use tools like Apollo, Mailshake or Reply.io to manage workflows and measure engagement, but personalize where it matters.

Plan 7–12 touchpoints across multiple channels: email, LinkedIn and calls. Add UTM codes or trackable links to measure performance and use A/B testing to refine what works.

For overseas-based teams expanding into the U.S., automation also helps maintain consistent brand voice across time zones and sales reps.

Continuous testing turns guesswork into predictable results.

Bringing It All Together

Cold outreach isn’t about sending more emails, it’s about starting real conversations, especially when you’re entering a new market or scaling a U.S. subsidiary.

The art builds connection and trust, the science ensures your message is seen and delivered effectively.

When empathy meets precision, communication feels human. People reply not because they must, but because it resonates.

The best campaigns don’t reach everyone. They reach the right person in the right way at the right time, and that’s where meaningful growth begins.